副主任:赵建龙 研究员
祥符实验室主任

教育背景

1987.09--1992.06   清华大学   学士

1992.09--1997.06   中科院上海冶金研究所   博士

1999.05--2001.11   中科院上海微系统所   副研究员

工作履历

1997.07-1999.04   中科院上海微系统所, 助理研究员

1999.05-2001.11   中科院上海微系统所, 副研究员

2001.11-   中科院上海微系统所, 研究院/博导

研究领域

主要从事生物芯片和生物传感器方面的研究,负责了中科院重大项目、上海市科委重大项目、国家863计划等多个重要科技项目,曾为中科院知识创新工程重大项目“生物芯片系统的研究与应用”首席科学家。研制成功了多种重要传染性疾病(乙肝、丙肝等)基因诊断芯片和尿蛋白检测分析仪,并实现成果转化。

研究方向

微电子

生物传感器

奖励与荣誉

申请了60多项发明专利,发表论文120余篇,其中SCI论文40余篇,获得1个国家一类新药证书,1个医疗器械产品注册证。2001年获上海市优秀科技启明星、2006年获上海市优秀学科带头人、2005年获上海市科技进步三等奖(排名第一)。 

(1) 面向城市安全治理的物联网关键技术及应用, 一等奖, 省级, 2022
(2) 基于微流控芯片技术的细胞通信研究与生物分子检测平台, 二等奖, 部委级, 2015
(3) 国家特殊津贴, 一等奖, 国家级, 2011
(4) 上海市领军人才, 一等奖, 省级, 2010

学术成果

1. Low-cost quantitative detection of nucleic acid using microbeads andmicrocolumn array chipZule, Sensors and Actuators B: Chemical, 2018, 第 8 作者

2Absolute quantification of DNA methylation using microfluidic chip-based digital PCR, Biosensors and Bioelectronics, 2017, 通讯作者

3Identifiation of long noncoding RNAs for the detection of early stage lung squamous cell carcinoma by microarray analysis, Oncotarget, 2017, 通讯作者
4Label-free graphene biosensor targeting cancer molecules based on non-covalent modification, Biosensors and Bioelectronics, 2017, 通讯作者
5Detection of KRAS mutations using double-stranded toehold-exchange probes, Biosensors and Bioelectronics, 2016, 通讯作者
6Absolute quantification of lung cancer related microRNA by droplet digital PCR, Biosensors and Bioelectronics, 2015, 通讯作者
7Identification of biomarkers for the detection of early stage lung adenocarcinoma by microarray profiling of long noncoding RNAs, Lung Cancer, 2015, 通讯作者
8Evaluation of a modified lateral flow immunoassay for detection of high-sensitivity cardiactroponinI and myoglobin, Biosensors and Bioelectronics, 2013, 通讯作者
9Integrated biochip for label-free and real-time detection of DNA amplification by contactless impedance measurements based on interdigitated electrodes, Biosensors and Bioelectronics, 2013, 通讯作者
10Sensitive lable-free oligonucleotide-based microfluidic detection of mercury ion by using exonuclease I, Biosensors and Bioelectronics, 2012, 通讯作者
11Highly Sensitive and Selective Chip-Based Fluorescent Sensor for Mercuric Ion: Development and Comparison of Turn-On and Turn-Off Systems, Analytical Chemistry, 2012, 通讯作者
12Real-time monitoring of strand-displacement DNA amplification by a contactless electrochemical microsystem using interdigitated electrodes, Lab chip, 2012, 通讯作者
13A simple poly(dimethylsiloxane) electrophoresis microchip with an integrated contactless conductivity detector, Microchim Acta , 2011, 通讯作者

14Novel colorimetric enzyme immunoassay for the detection of carcinoembryonic antigen, Talanta , 2010 , 通讯作者
15A microfluidic chip for permeability assays of endothelial monolayer, Biomed Microdevices, 2010, 通讯作者
16Highly Sensitive detection of Lung Cancer Marker Carcinoembryonic Antigen Using Enzyme-Based Multi-Component Optical Nanoprobes, Analyst, 2010, 通讯作者
17Integrated microfluidic chip for endothelial cells culture and analysis exposed to a pulsatile and oscillatory shear stress, Lab Chip, 2009, 通讯作者